Differential Uridyl-diphosphate-Glucuronosyl Transferase 1A enzymatic arsenal explains the specific cytotoxicity of resveratrol towards tumor colorectal cells

Abstract excerpt

<title>Abstract</title> <p>Resveratrol belongs to the Bioactive Food Component (BFC) family. It seems admitted that its cytotoxic action impacts tumor cells and spares healthy cells, but the published proofs remain rare. We hypothesized that cells may differentially metabolize resveratrol and lead to different systemic impacts. For this, resveratrol metabolization was evaluated by ultra-high-performance liquid ch...

Topics

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• Cancer-related molecular mechanisms research
• Colorectal Cancer Treatments and Studies
• Gut microbiota and health
• Pancreatic and Hepatic Oncology Research
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine
• Tea Polyphenols and Effects
• Toxin Mechanisms and Immunotoxins

Identifiers and source

Literature Corpus work

8a03e028-79b9-58b7-bc86-c87796f0f087

DOI

10.21203/rs.3.rs-1707694/v1