Hereditary Decreased Cancer Risk: Reality or Mirage? A Review

Abstract excerpt

Most of the knowledge about germline related cancer risks emerged from pioneering studies of families with increased cancer incidence. This led to the discovery of the chapter of hereditary cancer predisposing syndromes. More than 50 syndromes have been identified and most of them have been thoroughly studied. While most germline studies focused on pathogenic variants that increase cancer risk (e.g. BRCA1/2, CHEK...

Topics

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• Breast Neoplasms
• Genetic Predisposition to Disease
• Genetic Testing
• Germ Cells
• Germ-Line Mutation
• Mutation
• Neoplasms
• Neoplastic Syndromes, Hereditary

Identifiers and source

Literature Corpus work

89236e99-ef97-59e1-93b1-05d35067fab1

DOI

10.32388/dcrtzv.2