Back to search

Article

High-level ceftazidime-avibactam resistance in <i>Escherichia coli</i> conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant

2023-02-04

Abstract excerpt

<h4>Objectives</h4> To characterize a bla CMY variant associated with ceftazidime-avibactam (CZA) resistance from a serially collected Escherichia coli isolate. <h4>Methods</h4> A patient with an intra-abdominal infection due to recurrent E. coli was treated with CZA. On day 48 of CZA therapy, E. coli with a CZA MIC of >256 mg/L was identified from abdominal drainage. Illumina WGS was performed on all isola...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
881b45f4-8a79-5141-a872-be83ab9d5b98
DOI
10.1101/2023.02.03.527067
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High-level ceftazidime-avibactam resistance in <i>Escherichia coli</i> conferred by the novel plasmid-mediated beta-lactamase CMY-185 variantDOI 10.1101/2023.02.03.527067
High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated β-lactamase CMY-185 variantSemantic proximity
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coliSemantic proximity
Ceftazidime–Avibactam Resistance in <i>Escherichia coli</i> Primarily Mediated by <i>bla</i> <sub>NDM-5</sub> with Emergent Ceftazidime–Avibactam/Aztreonam Resistance Linked to <i>bla</i> <sub>CMY-42</sub> VariantsSemantic proximity
A Novel CMY Variant Confers Transferable High-Level Resistance to Ceftazidime-Avibactam in Multidrug-Resistant EscherichiacoliSemantic proximity
Structural insights into the molecular mechanism of high-level ceftazidime–avibactam resistance conferred by CMY-185Semantic proximity
A high-resolution genomic and phenotypic analysis of resistance evolution of an<i>Escherichia coli</i>strain from a critical care patient treated with piperacillin/tazobactamSemantic proximity
Emergence of high-level aztreonam–avibactam and cefiderocol resistance following treatment of an NDM-producing Escherichia coli bloodstream isolate exhibiting reduced susceptibility to both agents at baselineSemantic proximity
An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam ResistanceSemantic proximity
Genetic Determinants Underlying the Progressive Phenotype of β-lactam/β-lactamase Inhibitor Resistance in <i>Escherichia coli</i>Semantic proximity
Variations in carbapenem resistance associated with the VIM-1 metallo-β-lactamase across the <i>Enterobacterales</i>Semantic proximity
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing EnterobacteriaceaeSemantic proximity
Intrinsic class C extended-spectrum β-lactamases mediate resistance to oxyimino-cephalosporins in Antarctic <i>Pseudomonas fluorescens</i> complex bacteriaSemantic proximity
Select a neighboring publication to make it the new centre.