Article
Metabolomic profiling revels systemic signatures of premature aging induced by Hutchinson-Gilford Progeria Syndrome
2019-02-19
Abstract excerpt
Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder. HGPS children present a high incidence of cardiovascular complications along with altered metabolic processes and accelerated aging process. No metabolic biomarker is known and the mechanisms underlying premature aging are not fully understood. The present study analysed plasma from six HGPS patients of both sexes (7.7±1.4 years old...
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Identifiers and source
- Literature Corpus work
- 878aef4e-1269-5851-ad04-719bce63f23f
- DOI
- 10.1101/554220