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Article

The Transcription Factors Elf-1 and GATA-1 Bind to Cell-Specific Enhancer Elements of Human High-Affinity IgE Receptor α-Chain Gene

1999-07-01

Abstract excerpt

Abstract Key regulatory regions necessary for the expression of the gene encoding FcεRI α-chain, a component of the high-affinity IgE receptor primarily responsible for IgE-dependent allergic response, were investigated. Two regions, −74/−69 and −55/−47, which contained binding motifs for proteins belonging to the Ets family and the GATA family, respectively, were shown to be necessary for the activation of the α-...

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Literature Corpus work
868c1247-c44f-509d-9eac-0b186282b447
DOI
10.4049/jimmunol.163.2.623
Open publication

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