Article
Multimerization of Zika Virus-NS5 causes a ciliopathy and forces premature neurogenesis
2019-08-04
Abstract excerpt
Zika virus ( ZikV ) is a flavivirus that infects neural tissues, causing congenital microcephaly. ZikV has evolved multiple mechanisms to restrict proliferation and enhance cell death, although the underlying cellular events involved remain unclear. Here we show that the ZikV-NS5 protein interacts with host proteins at the base of the primary cilia in neural progenitor cells, causing an atypical non-genetic cilio...
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Identifiers and source
- Literature Corpus work
- 865ae5f5-eead-5444-96f5-33bb8105629d
- DOI
- 10.1101/719625