Article

ECLIPSE: Exploring the dark proteome of ESKAPE pathogens through the sequence similarity network of the Protein Universe Atlas

2026-04-01

Abstract excerpt

<h4>Motivation</h4> The accelerating crisis of antimicrobial resistance among the critical, so-called ESKAPE bacterial pathogens demands the urgent identification of novel molecular targets. However, a substantial fraction of ESKAPE proteomes remains functionally uncharacterized, with many genes annotated as encoding hypothetical proteins. These protein sequences often lack significant similarity to known protein...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85c5e56d-04bf-5b51-b604-7330c472ee69
DOI: 10.64898/2026.03.30.715302

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ECLIPSE: Exploring the dark proteome of ESKAPE pathogens through the sequence similarity network of the Protein Universe AtlasDOI 10.64898/2026.03.30.715302Read

Panorama: A robust pangenome-based method for predicting and comparing biological systems across species.Semantic proximity Read

ITEP: an integrated toolkit for exploration of microbial pan-genomes.Semantic proximity Read

Essential and virulence-related protein interactions of pathogens revealed through deep learningSemantic proximity Read

Aiki-XP: leakage-controlled multimodal prediction of within-species relative protein expression at pan-bacterial scaleSemantic proximity Read

Bacterial proteome foundation model enhances functional prediction from enzymes to ecological interactionsSemantic proximity Read

ppIRIS: deep learning for proteome-wide prediction of bacterial protein-protein interactionsSemantic proximity Read

Network analysis of ten thousand genomes shed light on Pseudomonas diversity and classification.Semantic proximity Read

Prediction and Analysis of the Protein Interactome in Pseudomonas aeruginosa to Enable Network-Based Drug Target SelectionSemantic proximity Read

Secondary metabolite profiling of Pseudomonas aeruginosa isolates reveals rare genomic traitsSemantic proximity Read

Bacterial protein function prediction via multimodal deep learningSemantic proximity Read

AGNOSTOS-DB: a resource to unlock the uncharted regions of the coding sequence spaceSemantic proximity Read

Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra.Semantic proximity Read