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Prediction and Analysis of the Protein Interactome in Pseudomonas aeruginosa to Enable Network-Based Drug Target Selection

24 Jul 2012

Abstract excerpt

Pseudomonas aeruginosa (PA) is a ubiquitous opportunistic pathogen that is capable of causing highly problematic, chronic infections in cystic fibrosis and chronic obstructive pulmonary disease patients. With the increased prevalence of multi-drug resistant PA, the conventional "one gene, one drug, one disease" paradigm is losing effectiveness. Network pharmacology, on the other hand, may hold the promise of...

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PMID: 22848443
DOI: 10.1371/journal.pone.0041202

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