Early 2-Factor Transcription Factors Associated with Progression and Recurrence in Bevacizumab-Responsive Subtypes of Glioblastoma

Abstract excerpt

The early 2-factor (E2F) family of transcription factors, including E2F1-8, plays a critical role in apoptosis, metabolism, proliferation, and angiogenesis within glioblastoma (GBM). However, the specific functions of E2F transcription factors (E2Fs) and their impact on the malignancy of Bevacizumab (BVZ)-responsive GBM subtypes remain unclear. This study used data from The Cancer Genome Atlas (TCGA) and Gene Expr...

Topics

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• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Central Nervous System Neoplasms
• E2F Transcription Factors
• Immune System
• Protein Interaction Mapping
• RNA-Seq
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

8565f76e-ecc3-53c5-be12-d407744076b2

DOI

10.20944/preprints202405.1426.v1