Article

A sibling study of variation in parental mutation rates

2026-05-15

Abstract excerpt

People are born with variable numbers of de novo germline mutations (DNMs), depending primarily on the ages of their parents. To explore additional causes, we developed an approach to call DNMs from nucleotide differences between siblings in genomic regions inherited identical by descent from both parents. Applying it to whole genome sequences from 28,985 sibling pairs of diverse genetic ancestries present in the...

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Literature Corpus work: 84bbcdd9-35e1-5ef3-be0d-6f68b2517df4
DOI: 10.64898/2026.05.10.724105

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