Article

Elucidating a potential role of the infant gut microbiome on the bioavailability of L-tyrosine in phenylketonuria

2025-10-29

Abstract excerpt

<h4>Background</h4> Phenylketonuria (PKU) is an inherited metabolic disorder caused by phenylalanine hydroxylase (PAH) deficiency, leading to elevated L-phenylalanine and severe neurological damage if untreated. While phenylalanine-based biomarkers are diagnostic and phenylalanine levels correlate with disease severity, the clinical manifestations of PKU are heterogeneous. <h4>Results</h4> To identify additional...

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Literature Corpus work: 847f3fa3-20b9-5085-9941-97ca6137828d
DOI: 10.1101/2025.10.28.685037

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