Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder

Abstract excerpt

Lithium remains the gold-standard maintenance treatment for bipolar disorder (BD) and is distinguished by its unique anti-suicidal and neuroprotective properties. Beyond its established psychiatric efficacy, growing evidence suggests that lithium may modulate fundamental mechanisms of biological aging. In parallel, cellular senescence has emerged as a central process linking oxidative stress, chronic inflammation,...

Topics

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• Adenosine and Purinergic Signaling
• Alzheimer's disease research and treatments
• Bipolar Disorder and Treatment
• Circadian rhythm and melatonin
• Genetics, Aging, and Longevity in Model Organisms
• Genetics and Neurodevelopmental Disorders
• Neuroinflammation and Neurodegeneration Mechanisms
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

83d6d598-4565-58fa-b657-7a66ca599441

DOI

10.20944/preprints202606.1622.v1