Article

Sociodemographic Bias in Large Language Model Clinical Trial Screening

2025-11-17

Abstract excerpt

<h4>Background</h4> Large language models (LLMs) are increasingly used in randomized clinical trial (RCT) screening, but their potential for sociodemographic bias remains unclear. <h4>Objective</h4> To determine whether LLM-based trial screening judgments vary with patient sociodemographic characteristics when clinical details and eligibility criteria are held constant. <h4>Design, Setting, and Participants</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83a983c7-ab4c-5426-8272-34b12f638e48
DOI: 10.1101/2025.11.15.25340177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sociodemographic Bias in Large Language Model Clinical Trial ScreeningDOI 10.1101/2025.11.15.25340177Read

Reporting of socio-demographic characteristics of trial participants in infectious diseases clinical trials – a systematic reviewSemantic proximity Read

Inclusion in clinical research: cross-sectional study assessing potential barriers to informed consent in randomized controlled trials published in top general and internal medical journalsSemantic proximity Read

Racial and Ethnic Diversity in Clinical Studies Reported to ClinicalTrials.gov, 2009-2024Semantic proximity Read

Large Language Models in Randomized Controlled Trials DesignSemantic proximity Read

LLM-Guided Pain Management: Examining Socio-Demographic Gaps in Cancer vs non-Cancer casesSemantic proximity Read

Current State and Demographic Trends of Medically Underserved Populations in Rare Disease Research in the United StatesSemantic proximity Read

Beyond Metrics to Methods: A Scoping Review of Large Language Models for Detection of Social Drivers of Health in Clinical NotesSemantic proximity Read

Sociodemographic Predictors of Consent: A Protocol and Statistical Analysis Plan for a Nested Observational Study of Canadian Sites in the REVISE TrialSemantic proximity Read

A Systematic Review of Representation in Clinical Trials for Transthyretin Associated Cardiac Amyloidosis: Where Demographics Diverge from DiseaseSemantic proximity Read

Public Knowledge and Attitudes towards Clinical Trial Participation: A Mixed-Method Study in Pwani Region, TanzaniaSemantic proximity Read

Speaking the Language of Inclusion: Examining English Languages Requirements in Cardiovascular Digital Health TrialsSemantic proximity Read

A Framework for Inclusive and Accessible Clinical Research in Rare DiseasesSemantic proximity Read