Article

Characterization of autoimmune eye disease in association with Down's Syndrome

2023-05-03

Abstract excerpt

<title>Abstract</title> <p>Background Autoimmunity and deficiency of the transcription factor autoimmune regulator protein (AIRE) are known associations with Down Syndrome (DS). Lack of AIRE abrogates thymic tolerance. The autoimmune eye disease associated with DS has not been characterized. We identified a series of subjects with DS (n = 8) and uveitis. In 3 consecutive subjects, we tested the hypothesis that a...

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Literature Corpus work: 824a2136-4935-5579-a0db-03d811be4467
DOI: 10.21203/rs.3.rs-2766021/v1

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