Article

Structural insights into mechanisms of zinc scavenging by the <i>Candida albicans</i> zincophore Pra1

2025-01-09

Abstract excerpt

Candida albicans causes more than 400,000 life-threatening, and half a billion mucosal infections annually. In response to infection, the host limits availability of essential micronutrients, including zinc, to restrict growth of the invading pathogen. As assimilation of zinc is essential for C. albicans pathogenicity, its limitation induces the secretion of the zincophore protein Pra1 to scavenge zinc from the h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60d8b37e-cb34-5db0-a9ff-177934b30560
DOI: 10.1101/2025.01.09.632233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural insights into mechanisms of zinc scavenging by the <i>Candida albicans</i> zincophore Pra1DOI 10.1101/2025.01.09.632233Read

Zinc Homeostasis at the Bacteria/Host Interface—From Coordination Chemistry to Nutritional ImmunitySemantic proximity Read

An evolutionary perspective on zinc uptake by human fungal pathogensSemantic proximity Read

How metals fuel fungal virulence, yet promote anti-fungal immunitySemantic proximity Read

The Zinc Transport Systems and Their Regulation in Pathogenic FungiSemantic proximity Read

Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal proteinSemantic proximity Read

Role of zinc in growth, stress response and virulence gene expression of pathogenic Mucorale <i>Rhizopus arrhizus</i>Semantic proximity Read

Zinc Cluster Transcription Factors Alter Virulence in Candida albicansSemantic proximity Read

Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants.Semantic proximity Read

<i>Candida albicans</i> oropharyngeal infection is an exception to iron-based nutritional immunitySemantic proximity Read

Phenotypic analysis of a family of transcriptional regulators, the zinc cluster proteins, in the human fungal pathogen Candida glabrata.Semantic proximity Read

Copper at the Fungal Pathogen-Host AxisSemantic proximity Read

Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicansSemantic proximity Read