Article

Discovery of fungal-specific targets and inhibitors using chemical phenotyping of pathogenic spore germination

2021-02-06

Abstract excerpt

There is a critical need for new antifungal drugs; however, the lack of available fungal-specific targets is a major hurdle in the development of antifungal therapeutics. Spore germination is a differentiation process absent in humans that could harbor uncharacterized fungal-specific targets. To capitalize on this possibility, we developed novel phenotypic assays to identify and characterize inhibitors of spore ge...

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Literature Corpus work: 80e04ff5-fbbc-57e7-ad67-552034282a4c
DOI: 10.1101/2021.02.06.430071

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