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Metallo-protease Peptidase M84 from <i>Bacillus altitudinis</i> induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

2023-09-06

Abstract excerpt

In pursuit of isolating novel anticancer proteases from environmental microbial isolates, we have purified and identified an extracellular metallo-protease from Bacillus altitudinis named Peptidase M84. This protease selectively triggered apoptosis in human ovarian adenocarcinoma cells (PA-1, SKOV3) and mouse ovarian carcinoma cells (ID8), in addition to exhibiting no significant effect on normal human epithelial...

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Literature Corpus work
80923705-a6d3-59d1-af87-5fb8209f3ea0
DOI
10.1101/2023.09.06.556500
Open publication

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Metallo-protease Peptidase M84 from <i>Bacillus altitudinis</i> induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1DOI 10.1101/2023.09.06.556500
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