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Article

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

Neurology - 15 Dec 2015

Gijselinck Ilse, Van Mossevelde Sara, van der Zee Julie, Sieben Anne, Philtjens Stéphanie, Heeman Bavo, Engelborghs Sebastiaan, Vandenbulcke Mathieu, De Baets Greet, Bäumer Veerle, Cuijt Ivy, Van den Broeck Marleen, Peeters Karin, Mattheijssens Maria, Rousseau Frederic, Vandenberghe Rik, De Jonghe Peter, Cras Patrick, De Deyn Peter P, Martin Jean-Jacques, Cruts Marc, Van Broeckhoven Christine

Abstract excerpt

OBJECTIVE: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients. METHODS: We sequenced TBK1 in a hospital-based cohort of 482 unrelated patients with FTD and FTD-ALS and 147 patients with ALS and an extended Belgian...

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Identifiers

PMID: 26581300
DOI: 10.1212/WNL.0000000000002220
PMCID: PMC4691687

Genes

TBK1
GRN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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