Article

Increased bacterial taxonomic and functional diversity is associated with impaired rotavirus vaccine immunogenicity in infants from India and Malawi

2023-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The immunogenicity and effectiveness of oral rotavirus vaccines (ORVs) against severe rotavirus-associated gastroenteritis is impaired in low- and middle-income countries (LMICs) where the burden of disease is highest. Determining risk factors for impaired ORV response may help identify strategies to enhance vaccine effectiveness. In this study, we use metagenomic sequencing to provide a high-res...

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Literature Corpus work: 8020e294-9f51-5363-8567-bd88e5f8d1a6
DOI: 10.1101/2023.03.24.23287614

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