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A novel <i>SERPINE1-FOSB</i> fusion gene in a case of pseudomyogenic hemangioendothelioma results in activation of intact FOSB and the PI3K-AKT-mTOR signaling pathway and responsiveness to sirolimus

2021-05-23

Abstract excerpt

Pseudomyogenic hemangioendothelioma (PHE) is an extremely rare disease that affects mainly the young and more men than women. PHE are multicentric, locally aggressive, have low metastatic potential, and affect multiple tissue planes. Genetic aberrations are frequently detected in PHE and may play important roles in the occurrence, development, and treatment of this disease. In this study, we report a case of PHE w...

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Literature Corpus work
7f8ba93b-4370-5014-ae63-1a10c63decbe
DOI
10.1101/2021.05.22.445285
Open publication

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A novel <i>SERPINE1-FOSB</i> fusion gene in a case of pseudomyogenic hemangioendothelioma results in activation of intact FOSB and the PI3K-AKT-mTOR signaling pathway and responsiveness to sirolimusDOI 10.1101/2021.05.22.445285
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