Successful Deep Sedation with Remimazolam and Alfentanil in a Child Susceptible to Malignant Hyperthermia: A Case Report

Abstract excerpt

<title>Abstract</title> <p>Background Malignant hyperthermia (MH) is a life-threatening autosomal-dominant disorder caused by mutations in the ryanodine receptor 1 (RYR1) gene, leading to calcium dysregulation in skeletal muscle. Patients with genetically confirmed MH susceptibility must strictly avoid volatile anesthetics and succinylcholine. Intravenous deep sedation presents a viable alternative, yet evidence...

Topics

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• Adolescent
• Anesthesia, General
• Genetic Testing
• Malignant Hyperthermia
• Myotonic Dystrophy
• Myotonin-Protein Kinase
• Treatment Outcome
• Trinucleotide Repeat Expansion

Identifiers and source

Literature Corpus work

7f7b2a35-022e-5eda-866b-b003a0e0ed2f

DOI

10.21203/rs.3.rs-6150816/v1