Article

A multimodal foundation model linking histopathology and DNA methylation

2026-06-14

Abstract excerpt

Hematoxylin and eosin (H&E) slides are routinely available in cancer care, but molecular profiling often requires additional tissue processing and turnaround time. We introduce HistoMethyl, a DNA methylation-aware pathology foundation model that aligns whole-slide histopathology with matched genome-scale methylation beta-value profiles during pre-training while requiring only an H&E slide at inference. We evaluate...

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Literature Corpus work: 7f43c0c2-d3ee-5230-954b-b6d24be222dc
DOI: 10.64898/2026.06.11.731518

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