Article

<i>Ehrlichia</i> SLiM ligand mimetic activates Notch signaling in human monocytes

2022-01-15

Abstract excerpt

Ehrlichia chaffeensis evades innate host defenses by reprogramming the mononuclear phagocyte through mechanisms that involve exploitation of multiple evolutionarily conserved cellular signaling pathways including Notch. This immune evasion strategy is directed in part by tandem repeat protein (TRP) effectors. Specifically, the TRP120 effector activates and regulates Notch signaling through interactions with the No...

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Literature Corpus work: 7f2a198b-169e-561e-8fbf-1f4b6896c4b2
DOI: 10.1101/2022.01.13.476283

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