Article

Controlled microtrauma opens a regenerative window for appendage-bearing skin repair

2026-06-23

Abstract excerpt

Adult skin normally resolves injury through rapid closure and fibrotic matrix deposition, often at the cost of permanent appendage loss. We tested whether spatially controlled microtrauma could instead serve as a regenerative entry point when paired with temporally coordinated molecular cues. We engineered a hierarchical extracellular-matrix-based microneedle patch that combines rapid local availability of vertepo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7eb72d73-26fc-5be4-a19a-334cd241ea35
DOI: 10.64898/2026.06.18.732512

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Controlled microtrauma opens a regenerative window for appendage-bearing skin repairDOI 10.64898/2026.06.18.732512Read

Live Imaging of Cutaneous Wound Healing in ZebrafishSemantic proximity Read

Recent Advances in Wound Healing, Tissue Repair, Regeneration and Scar ManagementSemantic proximity Read

Tower-shaped Super-adhesive Microneedles Loaded with Vitamin A-Containing Bletilla striata Vesicles: Temporally Regulated Inflammation Resolution and ECM Remodeling for Scarless Wound HealingSemantic proximity Read

Emerging technologies in regenerative medicine: The future of wound care and therapySemantic proximity Read

Comparative efficacy of multi micro-stimulation alveolar (MMSA) and traditional vacuum therapy on skin biomechanics integrity, and inflammationSemantic proximity Read

Live imaging the Foreign Body Response reveals how dampening inflammation reduces fibrosisSemantic proximity Read

Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?Semantic proximity Read

Wound healing in developmentSemantic proximity Read

<i>In vivo</i> reprogramming of wound-resident cells generates skin with hairSemantic proximity Read

Engineering a reproducible 3D wound model with defined macrophage polarization and partial-thickness mechanical injurySemantic proximity Read

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ MacrophagesSemantic proximity Read

A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injectionsSemantic proximity Read