Article

Oral Rotavirus Vaccine Shedding as a Marker of Mucosal Immunity

2021-08-19

Abstract excerpt

Rotavirus remains a leading cause of pediatric diarrhea worldwide, in part due to underperformance of currently approved live-attenuated, oral vaccines in low-and-middle income countries (LMIC). Improved immune correlates of protection (CoP) for existing oral vaccines and novel strategies to evaluate the performance of next-generation vaccines are needed. Use of oral vaccines as challenge agents in controlled huma...

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Literature Corpus work: 7ead98b1-c89a-5890-96fb-9cd105a6cb56
DOI: 10.21203/rs.3.rs-804029/v1

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