Article

Four decades of glioblastoma targeted therapy: a bibliometric and pharmacological perspective on translational failure and future directions

2026-05-25

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) remains highly resistant to targeted therapy despite four decades of molecular and translational research. To clarify the evolution and persistent translational barriers of this field, we performed a bibliometric and pharmacological analysis of 5,037 Web of Science Core Collection publications on GBM targeted therapy from 1985 to 2025. VOSviewer, CiteSpace, and biblio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e60120d-4dd8-584b-8210-59079c30fc83
DOI: 10.21203/rs.3.rs-9669872/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Four decades of glioblastoma targeted therapy: a bibliometric and pharmacological perspective on translational failure and future directionsDOI 10.21203/rs.3.rs-9669872/v1Read

Therapeutic Targets in Glioblastoma: Molecular Pathways, Emerging Strategies, and Future DirectionsSemantic proximity Read

KRAS-Targeting Agents in Cancer: A Bibliometric Analysis of Global Research Trends and Emerging Hotspots from 2006 to 2026Semantic proximity Read

Molecular matched targeted therapies for primary brain tumors-a single center retrospective analysis.Semantic proximity Read

Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatmentSemantic proximity Read

Molecular targeting of glioblastoma: Drug discovery and therapiesSemantic proximity Read

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.Semantic proximity Read

“The drug development pipeline for glioblastoma - a cross sectional assessment of the FDA Orphan Drug Product designation database”Semantic proximity Read

Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical ModelsSemantic proximity Read

The landscape of current research on pediatric diffuse midline glioma: a quantitative analysis of shifts, leaders, and future avenues.Semantic proximity Read

Frontiers and hotspots in induction chemotherapy of oral squamous cell carcinoma: a bibliometric and visualized study from 2000 to 2022 by Bioinformatics and Cancer Database AnalysisSemantic proximity Read

Mapping Topic Change in Influential Hepatocellular Carcinoma Research: A Two-Cohort Bibliometric AnalysisSemantic proximity Read