Article

Novel Synthetic Promoter Armed Oncolytic Herpes Simplex Virus For Treatment of PAX3-FOXO1 Positive Rhabdomyosarcoma

2026-06-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Due to the difficulty in targeting oncogenic transcription factors, there are no targeted treatments available for pediatric patients afflicted with PAX3-FOXO1 fusion positive alveolar rhabdomyosarcoma. Additionally, alveolar rhabdomyosarcomas are immunologically cold tumors inherently resistant to immune checkpoint blockade. Viral vectors present a unique opportunity to add...

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Literature Corpus work: 7e065efb-2864-5e09-baa6-b12f722a2195
DOI: 10.64898/2026.06.09.731216

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