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Irisin Alleviates Autoimmune Uveitis Through Promoting Retinal Microglial M1 to M2 Phenotypic Polarization Mediated by HIF-1α Pathway.

Inflammation - 1 Aug 2025

Wang Meiqi, Huang Xue, Shu Jia, Li Hongxi, Yang Tao, Li Na, Yang Peizeng

Abstract excerpt

Irisin, proteolytically cleaved from Fndc5 protein, has been identified as an exercise-related hormone. Here, we investigated the irisin levels in aqueous humor and its involvement in the pathogenesis of uveitis. The results revealed that the irisin level in the aqueous humor was significantly decreased in Vogt-Koyanagi-Harada (VKH), and Behcet uveitis (BU) patients, and was negatively correlated with TNF-α in BU...

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PMID: 39342514
DOI: 10.1007/s10753-024-02149-5

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