Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

Abstract excerpt

Atherosclerosis, a chronic inflammatory condition driving coronary artery disease (CAD), manifests in two primary plaque types: unstable atheromatous plaques and stable fibrous plaques. While significant research has focused on atheromatous plaques, recent studies emphasize the growing importance of fibrous plaques, particularly in females under 50 years of age, where erosion on fibrous plaques significantly contr...

Topics

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• Fibrosis
• Gene Regulatory Networks
• Muscle, Smooth, Vascular
• Myocytes, Smooth Muscle
• Myosin Heavy Chains
• Plaque, Atherosclerotic
• Proteomics
• Sex Factors

Identifiers and source

Literature Corpus work

7d480819-cc0e-5786-8c45-8788db27e26f

DOI

10.1101/2025.03.28.645955