Article

In silico identification of novel CDK4 inhibitors for retinoblastoma

2024-09-20

Abstract excerpt

• The over expression of CDK4 causes hyperphosphorylation of RB which causes transformation of normal retinal cell into retinoblastoma. • CDK4 is potent drug target to treat the retinoblastoma. • Compounds 3396 and 960 demonstrated the highest binding efficiency as novel inhibitors of CDK4. • Molecular dynamics simulation results confirm that the RMSD for these compounds remained below 3 Å, with additional binding...

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Literature Corpus work: 7d024336-cd0f-5882-be26-564ab97ca1ff
DOI: 10.1016/j.chphi.2024.100743

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