Back to search

Article

DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHES

2024-11-11

Abstract excerpt

This study aims to develop new molecular structures as potential therapeutic agents against COVID-19, utilizing both in silico and in vitro studies. Potential targets of cepharanthine (CEP) against COVID-19 to reveal its underlying mechanism of action were evaluated using in silico screening experiments. A library of new molecules was docked into the receptor binding domain of the SARS-CoV-2 spike glycoprotein com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7cd433cf-2fa6-5490-b0fd-34f80e8439d2
DOI
10.1101/2024.11.06.24316825
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHESDOI 10.1101/2024.11.06.24316825
Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus InfectionsSemantic proximity
Small molecules in the treatment of COVID-19Semantic proximity
Natural compounds as potential inhibitors of novel coronavirus (COVID-19) main protease: An in silico studySemantic proximity
Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico studySemantic proximity
Druggable targets and therapeutic development for COVID-19Semantic proximity
Identification of drugs targeting multiple viral and human proteins using computational analysis for repurposing against COVID-19Semantic proximity
A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseasesSemantic proximity
Interaction of Drug Candidates with Various SARS-CoV‑2 Receptors: An in Silico Study to Combat COVID-19Semantic proximity
In Silico Evaluation of Prospective Anti-COVID-19 Drug Candidates as Potential SARS-CoV-2 Main Protease InhibitorsSemantic proximity
Global multi-omics and systems pharmacological strategy unravel the multi-targeted therapeutic potential of natural bioactive molecules against COVID-19: An in silico approachSemantic proximity
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry PerspectiveSemantic proximity
An Overview of SARS-CoV-2 Potential Targets, Inhibitors, and Computational Insights to Enrich the Promising Treatment StrategiesSemantic proximity
Select a neighboring publication to make it the new centre.