Article
Factors influencing disease progression in autosomal dominant cerebellar ataxia and spastic paraplegia.
Archives of neurology - 1 Apr 2012
Tezenas du Montcel Sophie, Charles Perrine, Goizet Cyril, Marelli Cecilia, Ribai Pascale, Vincitorio Carlo, Anheim Mathieu, Guyant-Maréchal Lucie, Le Bayon Alice, Vandenberghe Nadia, Tchikviladzé Maya, Devos David, Le Ber Isabelle, N'Guyen Karine, Cazeneuve Cécile, Tallaksen Chantal, Brice Alexis, Durr Alexandra
Abstract excerpt
OBJECTIVES: To evaluate disease progression and determine validity of clinical tools for therapeutic trials. DESIGN: Prospective cohort study (36 months). SETTING: Referral center. PATIENTS: One hundred sixty-two patients with autosomal dominant cerebellar ataxia and 64 with hereditary spastic paraplegia. MAIN OUTCOME MEASURES: The quantitative Composite Cerebellar Functional Severity Score with the writing test...
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