Article

Human TBC1 domain-containing kinase is a class I multidomain pseudokinase

2026-04-03

Abstract excerpt

TBCK-related encephalopathy (TBCKE) is a neurodevelopmental disorder associated with biallelic mutations in TBCK . Despite the increasing number of reported cases worldwide, the biochemical and biophysical properties of TBCK remain unclear, hindering molecular understanding of its role in disease. Here, we present the successful expression, purification, and biochemical characterization of full-length human TBCK...

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Literature Corpus work: 7b9e18a4-534c-5c2e-88b9-b22128adc002
DOI: 10.64898/2026.04.02.716191

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