Article

Hereditary Carboxypeptidase N deficiency, a clinical situation presenting with urticaria and angioedema

2024-01-31

Abstract excerpt

<h4>Background: </h4> Carboxypeptidase N (CPN) plays a major role in anaphylatoxin inactivation and is critical for bradykinin catabolism. CPN deficiency is a rare and underdiagnosed condition. Its pathophysiology has been shown as a function of anaphylatoxin and kinin accumulation, prone to mast cell and endothelium activation and sustaining inflammatory processes. We aimed to study families with homogeneous pres...

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Literature Corpus work: 7b80a68b-a125-53ca-a15a-abfcd7fb4604
DOI: 10.22541/au.170668305.57822603/v1

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