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Article

Irritation Potential and Acute Efficacy of Topically Applied Niagen® (Niacinamide Riboside Chloride)

2026-03-20

Abstract excerpt

Human skin nicotinamide adenine dinucleotide (NAD+) levels decrease with age, likely contributing to the aging skin phenotype. It is hypothesized that topically applied NAD+ precursors, including niacinamide (nicotinamide) riboside (NR), may benefit skin aging. Three human clinical trials of topical Niagen®, NR chloride, were convened in healthy participants to evaluate its irritation potential; acute cosmetic NR...

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Literature Corpus work
7ae56652-ea26-56e7-9034-39b6d4919369
DOI
10.20944/preprints202603.1657.v1
Open publication

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