Article

Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low dose treatment of high-grade serous ovarian carcinoma

2023-04-03

Abstract excerpt

Ovarian cancer is driven by genetic alterations that necessitate protective DNA damage and replication stress responses through cell cycle control and genome maintenance. This creates specific vulnerabilities that may be exploited therapeutically. WEE1 kinase is a key cell cycle control kinase, and it has emerged as a promising cancer therapy target. However, adverse effects have limited its clinical progress, esp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ad42e66-d628-5d81-be3b-c5a291a06008
DOI: 10.1101/2023.03.31.535053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low dose treatment of high-grade serous ovarian carcinomaDOI 10.1101/2023.03.31.535053Read

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target.Semantic proximity Read

Combined inhibition of Chk1 and Wee1: In vitro synergistic effect translates to tumor growth inhibition in vivoSemantic proximity Read

Synthetic lethality in CCNE1-amplified high grade serous ovarian cancer through combined inhibition of Polo-like kinase 1 and microtubule dynamicsSemantic proximity Read

Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasisSemantic proximity Read

Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant ConcentrationsSemantic proximity Read

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitorsSemantic proximity Read

The CINs of Polo-Like Kinase 1 in CancerSemantic proximity Read

Inhibitors of cell cycle checkpoint target Wee1 kinase – a patent review (2003–2022)Semantic proximity Read

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapySemantic proximity Read

CRISPR Screening Identifies WEE1 as a Combination Target for Standard Chemotherapy in Malignant Pleural MesotheliomaSemantic proximity Read

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibitionSemantic proximity Read

MK1775, a Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity against Sarcoma CellsSemantic proximity Read