Article

Mechanistic Study of Deoxyshikonin-Mediated Protection Against High-Glucose-Induced Injury in HUVECs

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>Objective This study aimed to elucidate the mechanism by which deoxyshikonin (DS) ameliorates high-glucose-induced injury in human umbilical vein endothelial cells (HUVECs). Methods HUVECs were treated with different concentrations of DS, and cytotoxicity was assessed to determine a safe working concentration. A stable high-glucose injury model was established by exposing HUVECs to di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a8f72ce-03bb-58e9-8224-fa76c5251723
DOI: 10.21203/rs.3.rs-10221671/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanistic Study of Deoxyshikonin-Mediated Protection Against High-Glucose-Induced Injury in HUVECsDOI 10.21203/rs.3.rs-10221671/v1Read

Deoxyshikonin Ameliorates High Glucose-Induced Dysfunction of Human Umbilical Vein Endothelial Cells and Promotes Wound Healing in Diabetic Mice by Regulating hsa-HLA- DRB1Semantic proximity Read

Adropin is involved in the protective effect of ellagic acid against high-glucose induced injury in human umbilical venous endothelial CellsSemantic proximity Read

Key circRNAs, lncRNAs, and mRNAs of ShenQi Compound in protecting vascular endothelial cells from high glucose identified by whole transcriptome sequencingSemantic proximity Read

RNA-sequencing analysis reveals the potential mechanism by which a Dioscorea polystachya (Chinese yam) protein ameliorates hyperglycemia-induced endothelial dysfunctionSemantic proximity Read

Healing mechanism of diabetic foot ulcers using single-cell RNA-sequencingSemantic proximity Read

Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cellsSemantic proximity Read

Analysis of long non-coding RNA expression profiles in high-glucose treated vascular endothelial cellsSemantic proximity Read

Rosuvastatin Ameliorates High Glucose-induced Endothelial Cell Dysfunction through HIF-1 ActivationSemantic proximity Read

iPS-derived exosomes alleviate endothelial cell apoptosis and inflammation in Kawasaki disease through endogenous hsa-miR-1976 binding to CD40Semantic proximity Read

Identification of core genes and pathways in vacuum sealing drainage for the treatment of diabetic ulcers via bioinformatics and histologicalSemantic proximity Read

Circ_072697 knockdown promotes advanced glycation end products-induced cell proliferation and migration in HaCaT cells via miR-3150a-3p/KDM2A axisSemantic proximity Read

Hesperidin alleviates endothelial cell inflammation and apoptosis of Kawasaki disease through inhibiting the TLR4/IĸBα/NF-ĸB pathwaySemantic proximity Read