Article

Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium

2024-05-30

Abstract excerpt

<h4>Background</h4> Transplantation of mesenchymal stem cells or induced pluripotent stem cell derived cardiomyocytes improve heart function after myocardial infarction in pre-clinical models. Exosomes are extracellular vesicles, 30-150nm in size, which regulate the paracrine signal of the stem cells. We investigated the functional outcomes and biological effects of exosomes from pure populations of human bone ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 789c4d99-9678-58dc-80ca-5858e9b3873b
DOI: 10.1101/2024.05.29.596548

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured MyocardiumDOI 10.1101/2024.05.29.596548Read

Exosomes and cardioprotection - A critical analysis.Semantic proximity Read

Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived CardiomyocytesSemantic proximity Read

Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair.Semantic proximity Read

Mesenchymal stem cells derived exosomes: a new era in cardiac regenerationSemantic proximity Read

Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular ArrhythmiasSemantic proximity Read

Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart.Semantic proximity Read

Exosomal hsa_circ_0007047 Attenuates Pos-myocardial Infarction Remodeling by Promoting Angiogenesis via miR-1178-3p/PDPK1 AxisSemantic proximity Read

Mechanistic effects of mesenchymal and hematopoietic stem cells: New therapeutic targets in myocardial infarctionSemantic proximity Read

Exosomes for Intramyocardial Intercellular CommunicationSemantic proximity Read

Human umbilical cord mesenchymal stem cells derived Exosomes attenuate injury of myocardial infarction by miR-24-3p-promoted M2 macrophage polarizationSemantic proximity Read

Human hearts have an intrinsic regenerative potential following myocardial infarctionSemantic proximity Read

Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapySemantic proximity Read