Article
Primary immunodeficiency and chronic mucocutaneous candidiasis: pathophysiological, diagnostic, and therapeutic approaches.
Allergologia et immunopathologia - 1 Jan 2021
Egri Natalia, Esteve-Solé Ana, Deyà-Martínez Àngela, Ortiz de Landazuri Iñaki, Vlagea Alexandru, García A P, Cardozo Celia, Garcia-Vidal Carolina, Bartolomé Clara San, Español-Rego Marta, Yiyi L, Bosch-Amate Xavier, Ferrando J, Yagüe Jordi, Juan Manel, Alsina Laia
Abstract excerpt
Chronic mucocutaneous candidiasis (CMC) is characterized by a chronic or recurrent non-invasive infection, mainly due to Candida albicans, in skin, nails, and mucous membranes, associated in some cases with autoimmune manifestations. The key immune defect is a disruption of the action of cytokine IL-17, whose most common genetic etiology is STAT1 gene gain-of-function (GOF) mutations. The initial appropriate...
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