Article
Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation.
Frontiers in immunology - 1 Jan 2022
Lu Xiaodi, Zhang Keming, Jiang Weiwei, Li Hang, Huang Yue, Du Mingwei, Wan Jian, Cao Yanyun, Du Lin, Liu Xiaogang, Pan Weihua
Abstract excerpt
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membranes (e.g., mouth, esophagus, and vagina). Compared with that of other infectious diseases, the immune pathogenic mechanism of CMC is still poorly understood. We identified a signal transducer and activator of transcription 1 gain-of-function (c.Y289C) mutation in a CMC...
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