Article

Garetosmab, an inhibitor of activin A, reduces heterotopic ossification and flare-ups in adults with fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Fibrodysplasia ossificans progressiva (FOP), an ultra-rare disorder caused by mutations in the gene encoding activin A receptor type 1 ( ACVR1) , is characterized by painful flare-ups and cumulative heterotopic ossification (HO). Garetosmab, a fully-human monoclonal antibody blocking activin A, prevents HO in FOP mice. <h4>Methods</h4> LUMINA-1 ( NCT03188666 ) was a phase 2, m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 769aa014-cb5a-5302-a860-cd8e2ff6dc20
DOI: 10.1101/2023.01.11.23284254

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Garetosmab, an inhibitor of activin A, reduces heterotopic ossification and flare-ups in adults with fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trialDOI 10.1101/2023.01.11.23284254Read

How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans ProgressivaSemantic proximity Read

From mysteries to medicines: drug development for fibrodysplasia ossificans progressivaSemantic proximity Read

Fibrodysplasia ossificans progressiva.Semantic proximity Read

Recent progress in drug development for fibrodysplasia ossificans progressiva.Semantic proximity Read

Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).Semantic proximity Read

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-DependentSemantic proximity Read

Clinical Aspects and Current Therapeutic Approaches for FOPSemantic proximity Read

Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology.Semantic proximity Read

Fibrodysplasia ossificans progressiva emerges from obscurity.Semantic proximity Read

Fibrodysplasia ossificans progressiva: a blueprint for metamorphosisSemantic proximity Read

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva miceSemantic proximity Read

Fibrodysplasia ossificans progressiva: lessons learned from a rare disease.Semantic proximity Read