Article

Safety and immunogenicity of recombinant hepatitis E vaccine in healthy pregnant women between 14 and 34 weeks of gestation and non-pregnant women of reproductive age: Protocol for a Phase II, randomized, observer-blinded, placebo-controlled trial

2026-08-10

Abstract excerpt

<h4>Introduction</h4> Hepatitis E virus (HEV) in pregnancy is associated with high maternal and perinatal morbidity and mortality. The safety and efficacy of the recombinant protein HEV vaccine (HEV239, Hecolin ® ) have been established in non-pregnant adult populations but there is limited information among pregnant women. This trial has two co-primary objectives: 1) to assess pregnancy-related and/or serious s...

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Literature Corpus work: 768d4725-075b-5e2f-87e6-f95f5d54aaa4
DOI: 10.64898/2026.08.07.26359927

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Safety and immunogenicity of recombinant hepatitis E vaccine in healthy pregnant women between 14 and 34 weeks of gestation and non-pregnant women of reproductive age: Protocol for a Phase II, randomized, observer-blinded, placebo-controlled trialDOI 10.64898/2026.08.07.26359927Read

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