Article

The <i>LEPIS-HuR-TMOD4</i> axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis

2022-05-03

Abstract excerpt

Long noncoding RNAs (lncRNAs) play an important role in the entire progression of atherosclerosis. In this study, we identified an uncharacterized lncRNA, Liver Expressions by PSRC1 Induce Specifically ( LEPIS ). The expression of LEPIS and its potential target tropomodulin 4 ( TMOD4 ) in the liver of ApoE -/- mice fed a high-fat diet was increased. An ApoE -/- mouse model with the overexpression of LEPIS o...

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Identifiers and source

Literature Corpus work: 7524f637-e80a-5df0-a03b-c24467dd9dbb
DOI: 10.1101/2022.05.03.490400

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