Article
Identification of effective new drugs combinations exploiting the ability of trabectedin to modulate transcription
2017-01-01
Abstract excerpt
Ewing’s sarcoma (ES) is the second most common malignant bone tumor of childhood, characterized by the chimeric protein EWS-FLI1 (hallmark of this pathology), that alters the transcription of different genes. The five-year overall survival of patients with localized disease is approximately 70%; unfortunately the majority of patients with a metastatic disease have a poor prognosis with a five-year overall survival...
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Identifiers and source
- Literature Corpus work
- 7467841f-c15e-5780-91ad-c2da7cd94ac1
- DOI
- 10.21954/ou.ro.0000c2c0