Article

Functional Annotation of Human Long Non-Coding RNAs via Molecular Phenotyping

2019-07-14

Abstract excerpt

Long non-coding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes and yet, their functions remain largely unknown. We systematically knockdown 285 lncRNAs expression in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNA exhibite...

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Literature Corpus work: 734ab72b-218f-55d9-9a32-bcff72c89363
DOI: 10.1101/700864

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