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NAT2 genetic polymorphism and age dependent efficacy of neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells

2020-12-28

Abstract excerpt

<h4>Background: </h4> Intervertebral disc degeneration, one of the major causes of low-back pain, results from altered biosynthesis/turnover of extracellular matrix in the disc. Previously, we reported that the analgesic drug Neurotropin® (NTP) had an anabolic effect on glycosaminoglycan synthesis in cultured nucleus pulposus (NP) cells via the stimulation of chondroitin sulfate N -acetylgalactosaminyltransferase...

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Literature Corpus work
731572c5-6c82-5699-b8b2-53ad453a53e2
DOI
10.21203/rs.3.rs-131581/v1
Open publication

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