Article
Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study.
BMC medical genomics - 11 Mar 2021
Nakai Tomoko, Sakai Daisuke, Nakamura Yoshihiko, Horikita Natsumi, Matsushita Erika, Naiki Mitsuru, Watanabe Masahiko
Abstract excerpt
BACKGROUND: Intervertebral disc degeneration, one of the major causes of low-back pain, results from altered biosynthesis/turnover of extracellular matrix in the disc. Previously, we reported that the analgesic drug Neurotropin® (NTP) had an anabolic effect on glycosaminoglycan synthesis in cultured nucleus pulposus (NP) cells via the stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1....
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