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Ligand-receptor pair-based signature score Derived from On-treatment Tumor Specimens Predicts Immune Checkpoint Blockade Response in Metastatic Melanoma

2025-04-17

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade (ICB) therapy has transformed the treatment landscape for metastatic melanoma, yet predicting therapeutic response remains a significant challenge. This study hypothesizes that coordinated ligand-receptor (LR) interactions within the tumor microenvironment (TME) critically influence ICB efficacy and proposes that a novel LR pair-based signature score (LRPS) de...

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Literature Corpus work
72b10b05-6265-5e37-8db2-ea7f9ed8669a
DOI
10.21203/rs.3.rs-5854916/v1
Open publication

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Ligand-receptor pair-based signature score Derived from On-treatment Tumor Specimens Predicts Immune Checkpoint Blockade Response in Metastatic MelanomaDOI 10.21203/rs.3.rs-5854916/v1
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