Article

Microbial Peptidoglycan Engages Autophagy Receptor P62 to Induce Protective Mitophagy in the Liver

2025-07-01

Abstract excerpt

Although mitophagy is critical for maintaining mitochondrial integrity and hepatic homeostasis, the microbial-derived signals controlling this process remain unknown. Given the gut microbiota’s profound influence on liver pathophysiology, identifying specific bacterial factors that directly regulate hepatocyte mitophagy could unlock novel therapeutic strategies. In this study, we identify bacterial peptidoglycan (...

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Literature Corpus work: 728d6cab-3aa3-58f0-a0df-1303b4f69899
DOI: 10.1101/2025.06.27.662070

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