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Genomic Insights into Ceftazidime Resistance in <i>Burkholderia pseudomallei</i> : Discovery of A172T Mutation, and Palindromic GC-Rich Repeat Sequences Facilitating <i>penA</i> Duplication and Amplification

2025-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Ceftazidime (CAZ) resistance in Burkholderia pseudomallei , the causative agent of melioidosis, complicates treatment in endemic regions. This study identified a novel A172T mutation and other known penA mutations as critical contributors to CAZ resistance in a large Thai strain collection. Frequent gene duplication and amplification (GDA) of penA , likely driven by Palindromic GC-Rich Repeat...

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Literature Corpus work
72624e48-cec9-5304-84aa-d5e8ec15df48
DOI
10.1101/2025.02.11.637714
Open publication

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Genomic Insights into Ceftazidime Resistance in <i>Burkholderia pseudomallei</i> : Discovery of A172T Mutation, and Palindromic GC-Rich Repeat Sequences Facilitating <i>penA</i> Duplication and AmplificationDOI 10.1101/2025.02.11.637714
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